The evolution of Crohn's-associated E. coli

The Coombes lab is excited to share our latest research on how Crohn's disease-associated E. coli evolve in the host over time, published this month in Cell Host & Microbe. Led by postdoc Dr. Wael Elhenawy and PhD student Caressa Tsai, we showed that adherent-invasive E. coli (AIEC) evolve diverse traits during months of host colonization, including hypermotility and the ability to better consume nutrients in the gut. We also validated these traits in E. coli from Crohn's patients. Amazing work by the team here.