Psychological stress impairs IL22-driven protective gut mucosal immunity against colonising pathobionts

C.R. Shaler, A. Parco, W. Elhenawy, J. Dourka, J. Jury, E. F. Verdu, B. Coombes

High-throughput fitness screening and transcriptomics identify a role for a type IV secretion system in the pathogenesis of Crohn's disease-associated Escherichia coli

W. Elhenawy, S. Hordienko, S. Gould, A. Oberc, C. Tsai, T. Hubbard, M. Waldor, B. Coombes

Emergence of invasive Salmonella in Africa

C. Tsai, B. Coombes

(p)ppGpp-Dependent Regulation of the Nucleotide Hydrolase PpnN Confers Complement Resistance in Salmonella enterica Serovar Typhimurium

E. Chau, D. Perez-Morales, W. Elhenawy, V. Bustamante, Y. Zhang, B. Coombes

Targeting two-component systems uncovers a small-molecule inhibitor of Salmonella virulence

C. Tsai, C MacNair, M. Cao, J. Magolan, E. Brown, B. Coombes

Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling

E. Culp, N. Waglechner, A. Fiebig-Comyn, Y. Hsu, K. Koteva, D. Synchantha, B. Coombes, M. van Nieuwenhze, Y. Brun, G. Wright

Mimicking the human environment in mice reveals that inhibiting biotin synthesis is effective against antibiotic-resistant pathogens

L. Carfrae, C. MacNair, C. Brown, C. Tsai, B. Weber, S. Zlitni, V. Rao, J. Chun, M. Junop, B. Coombes, E. Brown

The Unique Lifestyle of Crohn's Disease-Associated Adherent-Invasive Escherichia coli

C. Shaler, W. Elhenawy, B. Coombes

Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2

A. Caminero, et al. 

Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis

M.S. Ladinsky, et al. 

Host-Specific Adaptive Diversification of Crohn’s Disease-Associated Adherent-Invasive Escherichia coli

W. Elhenawy, C. Tsai, B. Coombes

A macrophage-based screen identifies antibacterial compounds selective for intracellular SalmonellaTyphimurium

M. Ellis, C. Tsai, J. Johnson, S. French, W. Elhenawy, S. Porwollik, H. Andrews-Polymenis, M. McClelland, J. Magolan, B. Coombes, E. Brown

Regulatory Evolution Drives Evasion of Host Inflammasomes by Salmonella Typhimurium

B. Ilyas, D. Mulder, D. Little, W. Elhenawy, M. Branda, D. Perez-Morales, C. Tsai, N YE Chau, V. Bustamante, B. Coombes

Molecular basis for CesT recognition of type 3 secretion effectors in enteropathogenic E. coli

D. Little, B. Coombes

Functional diversification of the NleG effector family in enterohemorrhagic Escherichia coli

D. Valleau, D. Little, D. Borek, T. Skarina, A. Quaile, R. Di Leo, S. Houliston, A. Lemak, C. Arrowsmith, B. Coombes, A. Savchenko

Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance

J. Stokes, C. MacNair, B. Ilyas, S. French, J. Cote, C. Bouwman, M. Farha, A. Sieron, C. Whitfield, B. Coombes, E. Brown

Acute infectious gastroenteritis potentiates a Crohn's disease pathobiont to fuel ongoing inflammation in the post-infectious period

C. Small, L. Xing, J. McPhee, H. Law, B. Coombes

Aspergillomarasmine A overcomes metallo-beta-lactamase antibiotic resistance

A. King, S. Reid-Yu, W. Wang, D. King, G. De Pascale, N. Stranadka, T. Walsh, B. Coombes, G. Wright

Persistent infection with Crohn’s disease-associated adherent-invasive Escherichia coli leads to chronic inflammation and intestinal fibrosis

C. Small, S. Reid-Yu, J. McPhee, B. Coombes