New research was published today from a great collaboration between the Coombes and Brown labs in Nature Communications, identifying a chemical scaffold that selectively kills intracellular Salmonella. In chasing this lead, some cool new intracellular biology was uncovered too, showing that the Salmonella outer membrane is compromised in the macrophage, making the bacteria sensitive to otherwise ineffective small molecules. Could be great leads here for other intracellular Gram-negative bacteria too. Outstanding effort by PhD student Caressa Tsai and postdoc Mike Ellis, who were co-first authors. Great example of the power of collaboration across different lab and disciplines, which also required skilled med chem from the Magolan lab - would not have been possible otherwise!
Read the paper here and the "Behind the Paper" feature from the first authors here.